Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609823 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL7445274 | 0.93 | MAPT (0.44) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL7445278 | 0.93 | MAPT (0.44) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL1465907 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL1465908 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL6438274 | 0.89 | KDM4A (0.49) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL6438285 | 0.89 | KDM4A (0.49) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL13365085 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MAPTCYP3A4VCAM1TSHR | |
| SCHEMBL11614092 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4MAPK1KDM4A | |
| SCHEMBL11834600 | 0.76 | BACE1 (0.50) | ALDH1A1MAPTVCAM1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706524-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5- 2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-0706524-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5- 2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995000510-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 5-[2-(4-(BENZOISOTHIAZOL-3-YL)-PIPERAZIN-1-YL)ETHYL]-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE | PFIZER INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| US-5359068-A | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one | PFIZER INC. (US) | 1994-10-25 | — | — | US | disclosed |