Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605289 | 0.88 | SLC6A2 (0.34) | CTSKCTSLCTSBCTSSSLC6A2 | |
| SCHEMBL6680862 | 0.78 | CTSK (0.33) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5138705 | 0.77 | CTSK (0.54) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5138704 | 0.77 | CTSK (0.54) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5138706 | 0.77 | CTSK (0.54) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5138993 | 0.74 | CTSK (0.54) | CTSKCTSLCTSBCTSSCETP | |
| SCHEMBL5138994 | 0.74 | CTSK (0.54) | CTSKCTSLCTSBCTSSCETP | |
| SCHEMBL5138991 | 0.74 | CTSK (0.54) | CTSKCTSLCTSBCTSSCETP | |
| SCHEMBL4765103 | 0.72 | HCRTR1 (0.34) | CTSKCTSLCTSBCTSSKCNH2 | |
| SCHEMBL6589591 | 0.68 | CTSK (0.34) | CTSKCTSLCTSBCTSSSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |