Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287085 | 0.92 | PARP10 (0.39) | CYP11B1CYP11B2PARP10PARP11CYP19A1 | |
| SCHEMBL4373864 | 0.88 | MAPK14 (0.32) | PARP10PARP11MAPTALDH1A1HSD17B10 | |
| SCHEMBL4367402 | 0.81 | MAPK14 (0.35) | TDP2GSK3BLMNA | |
| SCHEMBL8114848 | 0.79 | CYP2C9 (0.36) | CYP2C9GAAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4373619 | 0.79 | GRIA1 (0.37) | CYP2C9GAAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4582205 | 0.76 | KDM4E (0.34) | CYP2C9CYP2C19TDP2GAAL3MBTL1 | |
| SCHEMBL14287092 | 0.76 | TDP2 (0.35) | TDP2GAABRAFMAPTSMN1; SMN2 | |
| SCHEMBL14287096 | 0.75 | ALOX15 (0.40) | PARP10PARP11TDP2GAAGSK3B | |
| SCHEMBL14287097 | 0.75 | MAPK14 (0.35) | PARP10PARP11 | |
| Hydrochloric Acid SCHEMBL8102952 | 0.75 | ADORA2A (0.33) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869958-B1 | NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES | NEUROSEARCH AS (DK) | 2004-12-29 | — | — | EP | disclosed |
| EP-1066037-B1 | USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS | NEUROSEARCH AS (DK) | 2004-12-29 | — | — | EP | disclosed |
| US-6693111-B1 | 1H-PYRROLO(3,2-H)ISOQUINOLINE DERIVATIVES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | NEUROSEARCH A/S (DK) | 2004-02-17 | — | — | US | disclosed |
| US-RE38200-E1 | Capable of antagonizing effect of excitatory amino acids, such as glutamate | NEUROSEARCH A/S (DK) | 2003-07-22 | — | — | US | disclosed |
| US-6239128-B1 | COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, | NEUROSEARCH A/S (DK) | 2001-05-29 | — | — | US | disclosed |
| EP-1066037-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE | NEUROSEARCH A/S (DK) | 2001-01-10 | — | — | EP | disclosed |
| US-6124285-A | Indole-2,3-dione-3-oxime derivatives | NEUROSEARCH A/S (DK) | 2000-09-26 | — | — | US | disclosed |
| EP-0781284-B1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| WO-1999049864-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE | NEUROSEARCH A/S (DK) | 1999-10-07 | — | — | WO | disclosed |
| US-5917053-A | INHIBITING GABA RELEASE FROM NEURONS | NEUROSEARCH A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| US-5843945-A | AMPA antagonists and a method of treatment | NEUROSEARCH A/S (DK) | 1998-12-01 | — | — | US | disclosed |
| EP-0869958-A1 | NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES | NEUROSEARCH A/S (DK) | 1998-10-14 | — | — | EP | disclosed |
| WO-1998014447-A1 | NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES | NEUROSEARCH A/S (DK) | 1998-04-09 | — | — | WO | disclosed |
| EP-0698025-B1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH AS (DK) | 1997-12-17 | — | — | EP | disclosed |
| EP-0781284-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008494-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |
| EP-0698025-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026747-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1994-11-24 | — | — | WO | disclosed |