Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 7/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27413094 | 0.94 | LMNA (0.36) | LMNAMAPK1SCN9ATSHRSCN4A | |
| SCHEMBL11709141 | 0.79 | LMNA (0.31) | LMNAMAPK1SCN9ATSHRSCN4A | |
| SCHEMBL9527213 | 0.79 | LMNA (0.31) | LMNAMAPK1SCN9ATSHRSCN4A | |
| SCHEMBL7334709 | 0.76 | LMNA (0.47) | LMNAMAPK1SCN9ATSHRSCN4A | |
| SCHEMBL11389444 | 0.76 | MAPT (0.33) | P2RX4KDM4EPTBP1P2RX1P2RX3 | |
| SCHEMBL3523519 | 0.73 | LMNA (0.39) | LMNATSHRP2RX4KDM4EP2RX1 | |
| SCHEMBL7339454 | 0.73 | LMNA (0.40) | LMNAMAPK1SCN9ATSHRSCN4A | |
| SCHEMBL11276030 | 0.72 | MAOB (0.34) | KMT2AMEN1 | |
| SCHEMBL11868744 | 0.72 | MAPT (0.38) | LMNAMAPK1KDM4ENPSR1KMT2A | |
| SCHEMBL3635590 | 0.71 | P2RX4 (0.39) | LMNAMAPK1SCN9ATSHRSCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027042-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1027042-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018951-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-22 | — | — | WO | disclosed |