Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610529 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1HPGDMAPTRAB9A | |
| SCHEMBL6612381 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2HPGDMAPTRAB9APOLB | |
| SCHEMBL6612378 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2HPGDMAPTRAB9APOLB | |
| SCHEMBL6610154 | 0.89 | MAPT (0.38) | SMN1; SMN2HPGDMAPTRAB9ACYP1A2 | |
| SCHEMBL6610157 | 0.89 | MAPT (0.38) | SMN1; SMN2HPGDMAPTRAB9ACYP1A2 | |
| SCHEMBL6611593 | 0.89 | HDAC1 (0.39) | SMN1; SMN2L3MBTL1HPGDMAPTRAB9A | |
| SCHEMBL6611592 | 0.89 | HDAC1 (0.39) | SMN1; SMN2L3MBTL1HPGDMAPTRAB9A | |
| SCHEMBL16728161 | 0.81 | CES2 (0.50) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6609674 | 0.81 | MAOB (0.40) | SMN1; SMN2MAPTCYP1A2POLBALDH1A1 | |
| SCHEMBL6609669 | 0.81 | MAOB (0.40) | SMN1; SMN2MAPTCYP1A2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |
| EP-1140895-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040576-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-13 | — | — | WO | disclosed |