Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491042 | 0.88 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL5207334 | 0.86 | IKBKB (0.54) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1680689 | 0.84 | PTK2 (0.73) | PTK2MAPK8MAPK10HTTMEN1 | |
| Bicarbonate SCHEMBL5978736 | 0.82 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| Bicarbonate SCHEMBL5978745 | 0.82 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| Bicarbonate SCHEMBL5978731 | 0.81 | IKBKB (0.52) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1726430 | 0.78 | PTK2 (0.59) | PTK2MAPK8MAPK10IKBKBJAK2 | |
| SCHEMBL5556399 | 0.77 | IKBKB (0.46) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6670703 | 0.77 | MAPK8 (0.50) | PTK2MAPK8MAPK10HTTMEN1 | |
| SCHEMBL5105544 | 0.75 | MEN1 (0.59) | PTK2IKBKBJAK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| EP-1261600-B1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003010158-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |
| EP-1261600-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001058890-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | disclosed |