SCHEMBL1726430

SCHEMBL1726430

NC(=O)Nc1sccc1C(N)=O.c1cc2cc-2c1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTK2 Q05397 1/20 0.59
MAPK8 P45983 11/20 0.57
MAPK10 P53779 5/20 0.57
IKBKB O14920 1/20 0.56
JAK2 O60674 1/20 0.56
JAK3 P52333 1/20 0.56
HTT P42858 1/20 0.54
ALDH1A1 P00352 2/20 0.52
MAPT P10636 2/20 0.52
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
KMT2A Q03164 1/20 0.52
TP53 P04637 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680689 0.88 PTK2 (0.73) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL6611048 0.78 PTK2 (0.55) PTK2MAPK8MAPK10IKBKBJAK2
SCHEMBL29064722 0.76 MAPK8 (0.70) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL28676789 0.76 PTK2 (0.47) PTK2MAPK8MAPK10
SCHEMBL5550829 0.76 PTPN2 (0.68) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL11946878 0.76 PTK2 (0.71) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL13270043 0.76 PTK2 (0.71) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL23323409 0.75 PTK2 (0.69) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL5092793 0.75 PTK2 (1.00) PTK2MAPK8MAPK10HTTALDH1A1
SCHEMBL29064716 0.75 MAPK8 (0.53) PTK2MAPK8MAPK10NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250082652-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2025-03-13 US claimed
WO-2023131576-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2023-07-13 WO claimed
EP-4209213-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES Universität zu Köln (DE) 2023-07-12 EP claimed
US-20200390825-A1 PLURIPOTENT STEM CELL-DIRECTED MODEL OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE FOR DISEASE MECHANISM AND DRUG DISCOVERY UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2020-12-17 US claimed
US-20140163088-A1 COMPOUNDS, COMPOSITION, METHODS, TARGETS FOR CANCER THERAPY YU MING (US) 2014-06-12 US claimed
EP-2403497-A1 COMPOUNDS, COMPOSITIONS AND USE FOR ANTICANCER THERAPY Yu, Ming (CN) 2012-01-11 EP claimed
US-20110142815-A1 COMPOUNDS, COMPOSITION, METHODS, TARGETS FOR CANCER THERAPY YU MING 2011-06-16 US claimed
CN-101842095-A Formulations, methods and targets for tumor therapy MING YU 2010-09-22 CN claimed
WO-2010099731-A1 COMPOUNDS, COMPOSITIONS AND USE FOR ANTICANCER THERAPY YU MING (CN) 2010-09-10 WO claimed
EP-2178531-A2 METHODS, COMPOSITION, TARGETS FOR COMBINATIONAL CANCER TREATMENTS Yu, Ming (US) 2010-04-28 EP claimed
WO-2009006555-A2 METHODS, COMPOSITION, TARGETS FOR COMBINATIONAL CANCER TREATMENTS YU, MING (US) 2009-01-08 WO claimed
US-20250082652-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2025-03-13 US disclosed
WO-2023131576-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2023-07-13 WO disclosed
EP-4209213-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES Universität zu Köln (DE) 2023-07-12 EP disclosed
US-20200390825-A1 PLURIPOTENT STEM CELL-DIRECTED MODEL OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE FOR DISEASE MECHANISM AND DRUG DISCOVERY UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2020-12-17 US disclosed
WO-2010083240-A2 METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS RIGEL PHARMACEUTICALS, INC. (US) 2010-07-22 WO disclosed
US-20100179165-A1 METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS MIDCAP FINANCIAL TRUST 2010-07-15 US disclosed
US-20100179164-A1 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS MIDCAP FINANCIAL TRUST 2010-07-15 US disclosed
EP-2178531-A2 METHODS, COMPOSITION, TARGETS FOR COMBINATIONAL CANCER TREATMENTS Yu, Ming (US) 2010-04-28 EP disclosed
WO-2009006555-A2 METHODS, COMPOSITION, TARGETS FOR COMBINATIONAL CANCER TREATMENTS YU, MING (US) 2009-01-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179165-A1 METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS IL2, IL17A, IL23R PTK2 3635/4885MAPK8 3483/4885MAPK10 3356/4885
US-20100179164-A1 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS IL2, IL1B, IL1A PTK2 4196/4885MAPK8 2431/4885MAPK10 464/4885
US-20200390825-A1 PLURIPOTENT STEM CELL-DIRECTED MODEL OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE FOR DISEASE MECHANISM AND DRUG DISCOVERY PKD1, PKD2, VHL PTK2 1444/4885MAPK8 4108/4885MAPK10 3458/4885
US-20140163088-A1 COMPOUNDS, COMPOSITION, METHODS, TARGETS FOR CANCER THERAPY DDIT3, MCL1, BAX PTK2 315/4885MAPK8 154/4885MAPK10 241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.