Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608759 | 0.89 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL6617034 | 0.89 | MTNR1A (0.46) | MAPTMTNR1BTSHRALDH1A1MTNR1A | |
| SCHEMBL6610719 | 0.87 | SLC2A1 (0.45) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL6612072 | 0.87 | MTNR1A (0.40) | MAPTMTNR1BTSHRALDH1A1MEN1 | |
| SCHEMBL6612194 | 0.87 | MAPT (0.39) | MAPTMTNR1BTSHRALDH1A1MEN1 | |
| SCHEMBL6615199 | 0.86 | MAPK1 (0.47) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6613814 | 0.85 | MAPT (0.38) | MAPTMTNR1BTSHRALDH1A1MEN1 | |
| SCHEMBL6610127 | 0.85 | MAPT (0.38) | MAPTMTNR1BTSHRALDH1A1MEN1 | |
| SCHEMBL5842932 | 0.85 | MAPT (0.60) | MAPTMTNR1BTSHRALDH1A1KMT2A | |
| SCHEMBL6613763 | 0.85 | MAPT (0.52) | MAPTMTNR1BTSHRALDH1A1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |