Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609407 | 0.94 | MAPT (0.54) | MAPK1POLBMAPTKMT2ATP53 | |
| SCHEMBL6610923 | 0.90 | HSD17B10 (0.42) | MAPTKMT2ATP53MEN1SMN1; SMN2 | |
| SCHEMBL6616178 | 0.90 | SMN1; SMN2 (0.47) | POLBMAPTKMT2AMEN1GAA | |
| SCHEMBL6614360 | 0.88 | MEN1 (0.41) | POLBMAPTKMT2ATP53MEN1 | |
| SCHEMBL6611273 | 0.87 | MAPT (0.48) | MAPTEPHX2KMT2ATP53MEN1 | |
| SCHEMBL6608607 | 0.87 | HSD17B10 (0.40) | MAPTKMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL6609911 | 0.87 | MAPT (0.43) | MAPTTP53SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL6614799 | 0.87 | MAPT (0.50) | MAPK1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6608759 | 0.87 | MAPT (0.43) | MAPTKMT2ATP53MEN1SMN1; SMN2 | |
| SCHEMBL6611071 | 0.86 | MAPT (0.43) | POLBMAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |