Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993953 | 0.83 | CYP1A2 (0.45) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL27599100 | 0.83 | ALDH1A1 (0.62) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8993978 | 0.82 | CYP1A2 (0.44) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL27599056 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1TDP1KMT2ACYP1A2 | |
| SCHEMBL5842818 | 0.82 | MAPT (0.44) | SMN1; SMN2ALDH1A1TDP1MAPK1CYP1A2 | |
| SCHEMBL7714031 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8993946 | 0.79 | CYP1A2 (0.46) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8993951 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2ALOX5CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL2440814 | 0.77 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TDP1MAPK1KMT2A | |
| SCHEMBL18979908 | 0.76 | CYP3A4 (0.56) | ALDH1A1TDP1MAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1610678-A | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-27 | — | — | CN | claimed |
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | claimed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | claimed |
| CN-100534990-C | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | CN | disclosed |
| CN-1610678-A | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-27 | — | — | CN | disclosed |