Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447605 | 0.96 | CHRNB4 (0.53) | LTA4HCHRNB4CHRNA3SLC6A4HRH1 | |
| SCHEMBL14578215 | 0.86 | CHRNB4 (0.52) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL11459383 | 0.85 | LTA4H (0.52) | LTA4HSLC6A4 | |
| SCHEMBL8290264 | 0.84 | CHRNB4 (0.68) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL9237631 | 0.84 | CHRNB4 (0.68) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL4965391 | 0.83 | LTA4H (0.64) | LTA4H | |
| Hydrochloric Acid SCHEMBL9241805 | 0.83 | CHRNB4 (0.67) | LTA4HCHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL9241795 | 0.83 | CHRNB4 (0.67) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL11447769 | 0.82 | KDM4E (0.49) | LTA4HCHRNB4CHRNA3 | |
| SCHEMBL11455586 | 0.82 | CHRNB4 (0.69) | LTA4HCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435955-A2 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SmithKline Beecham P.L.C. (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2002089800-A2 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |