Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.39 |
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611995 | 1.00 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6605364 | 0.88 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6605361 | 0.88 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6609424 | 0.85 | CHEK1 (0.35) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6606975 | 0.85 | CHEK1 (0.35) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6609466 | 0.83 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6609471 | 0.83 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6607216 | 0.83 | PDE4B (0.38) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6607223 | 0.83 | PDE4B (0.38) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL6609780 | 0.80 | PDE4B (0.44) | PDE4DPDE4APDE4BPDE4CEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |