Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.54 |
| ▸ | MMP13 | P45452 | 20/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 20/20 | 0.54 |
| ▸ | MMP9 | P14780 | 15/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608829 | 0.93 | MMP13 (0.55) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6608737 | 0.88 | MMP1 (0.64) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6643562 | 0.84 | MMP13 (0.65) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6608927 | 0.83 | MMP1 (0.53) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6609973 | 0.82 | MMP1 (0.60) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6612053 | 0.81 | MMP1 (0.58) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6614380 | 0.81 | MMP1 (0.67) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6614483 | 0.81 | MMP1 (0.62) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6642639 | 0.80 | MMP13 (0.66) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6644293 | 0.80 | MMP1 (0.58) | MMP1MMP13ADAM17MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147095-B1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1147095-A1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044730-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]BENZODIAZEPINE-3-HYDROXAMIC ACID AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |