Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.42 |
| ▸ | RELA | Q04206 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | C1R | P00736 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721722 | 0.82 | TARBP2 (0.50) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL5216035 | 0.80 | TARBP2 (0.54) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL6614503 | 0.73 | ALOX5 (0.43) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4473982 | 0.72 | PTPN1 (0.48) | MAPTTP53HDAC1HDAC8HDAC6 | |
| SCHEMBL5220019 | 0.71 | TARBP2 (0.38) | MAPTTP53HSD17B10KDM4ELMNA | |
| SCHEMBL4470229 | 0.69 | KMT2A (0.42) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL31042985 | 0.68 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL31383801 | 0.67 | CYP2C19 (0.49) | ALDH1A1HPGDLMNAKMT2APOLB | |
| SCHEMBL1345452 | 0.67 | CYP2C19 (0.49) | ALDH1A1HPGDLMNAKMT2APOLB | |
| SCHEMBL8573767 | 0.66 | GAA (0.51) | MAPTSMN1; SMN2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480640-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072100-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |