Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14365390 | 0.93 | CHRM2 (0.57) | HTTCHRM2MEN1KMT2ATAAR1 | |
| SCHEMBL607175 | 0.85 | HTT (0.67) | HTTCHRM2MEN1KMT2APKM | |
| SCHEMBL40401 | 0.82 | CHRM2 (0.69) | HTTCHRM2MEN1KMT2ATAAR1 | |
| SCHEMBL25375887 | 0.82 | HTT (0.55) | HTTCHRM2MEN1KMT2AHPGD | |
| SCHEMBL14492294 | 0.82 | MAPK1 (0.60) | HTTCHRM2MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6065696 | 0.80 | CHRM2 (0.67) | HTTCHRM2MEN1KMT2ATAAR1 | |
| SCHEMBL14820047 | 0.79 | ALDH1A1 (0.54) | TAAR1ALDH1A1L3MBTL1 | |
| SCHEMBL9080908 | 0.78 | KDM4E (0.56) | HTTCHRM2MEN1KMT2APKM | |
| SCHEMBL2125786 | 0.78 | TDP1 (0.55) | HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8771511 | 0.77 | CYP3A4 (0.58) | TAAR1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313732-B1 | OXINDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-11-03 | — | — | EP | disclosed |
| EP-1313732-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002020524-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-03-14 | — | — | WO | disclosed |