Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | GIPR | P48546 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607130 | 0.93 | TNFRSF1A (0.39) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL6804198 | 0.91 | MAPT (0.40) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL6602793 | 0.90 | CHEK1 (0.38) | CHEK1CHEK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6602115 | 0.88 | TNFRSF1A (0.35) | ALDH1A1KDM4EMAPTGCGRGIPR | |
| SCHEMBL6613906 | 0.86 | CHEK2 (0.38) | CHEK1CHEK2ALDH1A1MAPTGCGR | |
| SCHEMBL6604701 | 0.83 | TNFRSF1A (0.39) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL6607115 | 0.82 | ACLY (0.39) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL6602350 | 0.81 | GCGR (0.36) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL6602442 | 0.79 | ALDH1A1 (0.36) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL6801015 | 0.79 | SMPD3 (0.38) | ALDH1A1KDM4EMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-1432689-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| EP-1427725-A1 | PYRAZOLYL-SUBSTITUTED THIENYLOXYPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 2004-06-16 | — | — | EP | disclosed |
| WO-2004007467-A1 | NOVEL 3-(3-[AMINOSULFONYLAMINO]-4-CYANO-PHENYL)-6-TRIFLUOROMETHYL-URACILS | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-22 | — | — | WO | disclosed |
| EP-1315733-A2 | METHOD FOR PRODUCING ANELLATED TETRAHYDRO-[1H]-TRIAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 2003-06-04 | — | — | EP | disclosed |
| WO-2003029243-A2 | 2-ARYLOXY-6-PYRAZOLYL-PYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 2003-04-10 | — | — | WO | disclosed |
| WO-2003027074-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| WO-2003022843-A1 | PYRAZOLYL-SUBSTITUTED THIENYLOXYPYRIDINES | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-20 | — | — | WO | disclosed |
| EP-1286991-A2 | CYCLOPROPYL-ANELLATED 3-(4,5-DIHYDROISOXAZOL-3-YL)-SUBSTITUED BENZOYLPYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-05 | — | — | EP | disclosed |
| EP-1284969-A1 | 3-(4,5-DIHYDROISOXAZOLE-5-YL)BENZOYLCYCLOHEXENONES AND THE USE THEREOF AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2003-02-26 | — | — | EP | disclosed |
| WO-1998050366-A1 | SUBSTITUTED 4-(3-ALKENYL-BENZOYL)-PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998050337-A1 | SUBSTITUTED 2-(3-ALKENYL-BENZOYL)-CYCLOHEXANE-1,3-DIONES | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998042682-A1 | NOVEL 1-AMINO-3 BENZYL URACILS | BASF AKTIENGESELLSCHAFT (DE) | 1998-10-01 | — | — | WO | disclosed |
| WO-1998042681-A1 | NOVEL HERBICIDAL HYDROXIMIC ACID DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1998-10-01 | — | — | WO | disclosed |
| WO-1998031681-A1 | 3-HETEROCYCLYL-SUBSTITUTED BENZOYL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1998-07-23 | — | — | WO | disclosed |
| EP-0835248-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997035845-A1 | SUBSTITUTED 1-METHYL-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-02 | — | — | WO | disclosed |
| WO-1997001543-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-01-16 | — | — | WO | disclosed |
| EP-0637298-A1 | SUBSTITUTED CYCLOHEXENE-1,2-BICARBOXYLIC ACID DERIVATIVES AND RAW MATERIALS FOR PRODUCING THEM | BASF Aktiengesellschaft (DE) | 1995-02-08 | — | — | EP | disclosed |
| EP-0599906-A1 | HERBICIDES CONTAINING 3-AMINOBENZO B]THIOPHENES AS AN ANTIDOTE. | BASF AG (DE) | 1994-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | CHEK1 653/4885CHEK2 957/4885ALDH1A1 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.