Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.58 |
| ▸ | BCL6 | P41182 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612030 | 0.91 | NAMPT (0.62) | NAMPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6615371 | 0.90 | ABCC9 (0.64) | NAMPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6614207 | 0.85 | ALDH1A1 (0.51) | NAMPTBCL6ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6067893 | 0.80 | BCL6 (0.58) | BCL6NPC1ALDH1A1KMT2AKDM4E | |
| SCHEMBL14096372 | 0.79 | NAMPT (0.72) | NAMPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4682799 | 0.77 | ABCC9 (0.82) | NAMPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL25752880 | 0.76 | PRSS1 (0.67) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6614054 | 0.75 | NAMPT (0.55) | NAMPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL167081 | 0.75 | NAMPT (1.00) | NAMPTNPC1RAB9ALMNAGAA | |
| SCHEMBL6643209 | 0.75 | CYP11B1 (0.58) | NAMPTNPC1RAB9ASMN1; SMN2ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | claimed |
| JP-2003506355-A | — | — | 2003-02-18 | — | — | JP | claimed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | claimed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | claimed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |