Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614346 | 0.86 | NR1H2 (0.44) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL6618500 | 0.85 | NR1H2 (0.39) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL6657656 | 0.83 | ITGA4 (0.41) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL7683608 | 0.80 | NR1H2 (0.44) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL6618635 | 0.80 | NR1H2 (0.44) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL6619143 | 0.78 | FNTA (0.49) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL6634181 | 0.78 | FNTA (0.49) | PTPN1HDAC8NR1H2NR1H3MEN1 | |
| SCHEMBL2957414 | 0.73 | MAPK1 (0.55) | NR1H2NR1H3MEN1KMT2AMAPK1 | |
| SCHEMBL10324269 | 0.73 | MAPK1 (0.55) | NR1H2NR1H3MEN1KMT2AMAPK1 | |
| SCHEMBL14130159 | 0.73 | MAPK1 (0.55) | HDAC8NR1H2NR1H3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |