Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 14/20 | 0.62 |
| ▸ | FNTB | P49356 | 14/20 | 0.62 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.40 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633140 | 0.86 | FNTA (0.47) | FNTAFNTBDAGLBDAGLACYP11B1 | |
| SCHEMBL6635731 | 0.85 | FNTA (0.56) | FNTAFNTBCA1CA2CA4 | |
| SCHEMBL6616410 | 0.79 | CYP11B2 (0.52) | FNTAFNTBDAGLBCYP11B1CYP11B2 | |
| SCHEMBL3498710 | 0.76 | FNTA (0.73) | FNTAFNTB | |
| SCHEMBL3498707 | 0.76 | FNTA (0.73) | FNTAFNTB | |
| SCHEMBL6613663 | 0.76 | FNTA (0.62) | FNTAFNTBGPR142DAGLBDAGLA | |
| SCHEMBL6637542 | 0.76 | FNTA (0.62) | FNTAFNTBGPR142DAGLBDAGLA | |
| SCHEMBL6635023 | 0.73 | FNTA (0.49) | FNTAFNTB | |
| SCHEMBL6623755 | 0.72 | FNTA (0.58) | FNTAFNTB | |
| SCHEMBL6623752 | 0.72 | FNTA (0.58) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |