Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 11/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633380 | 0.79 | MEN1 (0.56) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6615168 | 0.79 | MEN1 (0.56) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6617818 | 0.75 | TGM2 (0.35) | MEN1KMT2A | |
| SCHEMBL6618341 | 0.74 | MEN1 (0.51) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6618053 | 0.74 | MEN1 (0.68) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6616133 | 0.74 | MEN1 (0.68) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6616447 | 0.72 | MEN1 (0.51) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6615300 | 0.70 | MEN1 (0.46) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6614938 | 0.69 | MEN1 (0.51) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL6640477 | 0.69 | MEN1 (0.51) | PNMTADRA2AADRA2BADRA2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |