Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL7501745 | 0.92 | ALDH1A1 (0.38) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL7492970 | 0.84 | NR4A1 (0.37) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL6616108 | 0.80 | AURKA (0.44) | ALDH1A1GAA | |
| SCHEMBL8318831 | 0.77 | KDM4E (0.43) | MAPTSMN1; SMN2 | |
| SCHEMBL6616007 | 0.76 | KDM4E (0.42) | MAPTSMN1; SMN2 | |
| SCHEMBL11154939 | 0.74 | AURKA (0.46) | ALDH1A1NPC1RAB9AF2PRSS1 | |
| SCHEMBL6618259 | 0.73 | TDP1 (0.44) | ALDH1A1MEN1MAPTKMT2AAKR1C4 | |
| SCHEMBL6613577 | 0.73 | TDP1 (0.44) | ALDH1A1MEN1MAPTKMT2AAKR1C4 | |
| SCHEMBL29923859 | 0.72 | MEN1 (0.58) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL908565 | 0.72 | MEN1 (0.58) | PDGFRBFGFR1PDGFRAFLT1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906313-B1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1032384-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6271222-B1 | ANTIBIOTIC | MERCK & CO., INC. | 2001-08-07 | — | — | US | disclosed |
| US-6235898-B1 | CARBAPENEMS ARE SUBSTITUTED AT THE 2-POSITION WITH 1,8-NAPHTHOSULTAM-N-METHYL GROUPS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |
| US-6207823-B1 | ANTIBIOTIC; ANTIBIOTIC RESISTANT INFECTIONS | MERCK & CO., INC. | 2001-03-27 | — | — | US | disclosed |
| EP-1032384-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| US-6048978-A | Process for the synthesis of carbapenem intermediates, and compounds produced | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |
| US-5994343-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999020270-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| US-5756725-A | CARBAPENEM NUCLEUS IS SUBSTITUTED AT THE 2-POSITION WITH A NAPHTHOSULTAM LINKED THROUGH A CH2 GROUP | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |