Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615432 | 0.92 | PDGFRB (0.41) | ALDH1A1LMNAF2PRSS1PRSS2 | |
| SCHEMBL7492970 | 0.83 | NR4A1 (0.37) | ALDH1A1LMNAF2PRSS1PRSS2 | |
| Potassium Ion SCHEMBL6616004 | 0.83 | KDM4E (0.41) | MAPTSMN1; SMN2 | |
| SCHEMBL8318831 | 0.78 | KDM4E (0.43) | MAPTSMN1; SMN2 | |
| SCHEMBL6616007 | 0.77 | KDM4E (0.42) | MAPTSMN1; SMN2 | |
| SCHEMBL6616108 | 0.73 | AURKA (0.44) | ALDH1A1GAA | |
| SCHEMBL6616106 | 0.72 | NR4A1 (0.44) | ALDH1A1LMNAGAA | |
| SCHEMBL29923859 | 0.69 | MEN1 (0.58) | ALDH1A1MEN1MAPTKMT2APDGFRB | |
| SCHEMBL908565 | 0.69 | MEN1 (0.58) | ALDH1A1MEN1MAPTKMT2APDGFRB | |
| SCHEMBL13576829 | 0.69 | KDM4E (0.53) | ALDH1A1MAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082325-A4 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1027353-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1032384-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1023271-A4 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | MERCK & CO INC (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1082325-A1 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-1032384-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-1027353-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-1023271-A1 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999061448-A1 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | MERCK & CO., INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999020270-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999018078-A1 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018107-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |