Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615977 | 0.94 | LMNA (0.42) | LMNANAMPTP2RY14MAPTHDAC1 | |
| SCHEMBL6673259 | 0.93 | NAMPT (0.41) | NAMPTMAPTACKR3ROCK2POLB | |
| SCHEMBL6616947 | 0.91 | SSTR3 (0.43) | LMNANAMPTP2RY14MAPTPOLB | |
| SCHEMBL6613507 | 0.90 | MAPT (0.42) | LMNANAMPTP2RY14MAPTPOLB | |
| SCHEMBL6618083 | 0.90 | NAMPT (0.46) | NAMPTMAPTHDAC1JAK2TP53 | |
| SCHEMBL6614876 | 0.89 | MEN1 (0.43) | NAMPTMAPTHDAC1JAK2TP53 | |
| SCHEMBL6616488 | 0.89 | GCGR (0.43) | NAMPTEPHX2 | |
| SCHEMBL6603139 | 0.89 | BRAF (0.40) | LMNANAMPTMAPTROCK2POLB | |
| SCHEMBL6617364 | 0.87 | CNR1 (0.42) | NAMPTMAPTJAK2ACKR3POLB | |
| SCHEMBL6614591 | 0.87 | P2RY14 (0.42) | NAMPTP2RY14MAPTHDAC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |