Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651951 | 0.94 | P2RY14 (0.41) | P2RY14NAMPTMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL6619665 | 0.92 | P2RY14 (0.41) | P2RY14NAMPTMAPTPOLBROCK2 | |
| SCHEMBL6616371 | 0.91 | ACKR3 (0.43) | P2RY14MAPTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL6624191 | 0.90 | CRACR2A (0.46) | NAMPTMAPTSMN1; SMN2HDAC1ROCK2 | |
| SCHEMBL6615869 | 0.89 | NAMPT (0.41) | NAMPTMAPTSMN1; SMN2HDAC1ROCK2 | |
| SCHEMBL6619833 | 0.89 | TRPV1 (0.43) | NAMPT | |
| SCHEMBL6651075 | 0.89 | KMT2A (0.39) | NAMPTPOLBKDM4ETP53 | |
| SCHEMBL6613507 | 0.88 | MAPT (0.42) | P2RY14NAMPTMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6616947 | 0.87 | SSTR3 (0.43) | P2RY14NAMPTMAPTPOLB | |
| SCHEMBL6615537 | 0.87 | LMNA (0.45) | P2RY14NAMPTMAPTHDAC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |