Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610665 | 0.97 | MAPT (0.43) | MAPTALDH1A1KDM4EKMT2APPARG | |
| SCHEMBL6612265 | 0.93 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL6613477 | 0.81 | MAPK1 (0.47) | MAPTALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL6609547 | 0.80 | MAPT (0.48) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL6610260 | 0.80 | PLA2G1B (0.35) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4699755 | 0.73 | KMT2A (0.44) | MAPTALDH1A1KDM4EKMT2APPARG | |
| SCHEMBL7253909 | 0.72 | ALDH1A1 (0.42) | MAPTALDH1A1KDM4EKMT2APPARG | |
| SCHEMBL6612197 | 0.71 | PIK3CD (0.34) | — | |
| SCHEMBL5798941 | 0.71 | MAPT (0.51) | MAPTALDH1A1KDM4EKMT2APPARG | |
| SCHEMBL73947 | 0.70 | PDE4D (0.42) | MAPTALDH1A1KDM4EKMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261605-B1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2004-11-10 | — | — | EP | disclosed |
| EP-1261605-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-04 | — | — | EP | disclosed |
| US-6403791-B1 | TREATMENT OF INFLAMMATORY DISEASES OR AUTOIMMUNE DISEASES IN HUMANS OR ANIMALS | DARWIN DISCOVERY, LTD. (GB) | 2002-06-11 | — | — | US | disclosed |
| WO-2001058896-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |