Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636013 | 0.72 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2C | |
| Methylsulfanylmethane SCHEMBL6615849 | 0.70 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL27769158 | 0.69 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL383577 | 0.67 | PNMT (0.74) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29728441 | 0.67 | CHRNA7 (0.60) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL8607960 | 0.67 | CHRNA7 (0.60) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9277382 | 0.67 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL654053 | 0.67 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL1786988 | 0.66 | PNMT (0.72) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL19281510 | 0.66 | CHRNA7 (0.59) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |