Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615529 | 0.95 | MAPK14 (0.41) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6615668 | 0.91 | KDM4C (0.49) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6615628 | 0.88 | KDM4C (0.44) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6616130 | 0.87 | ASAH1 (0.38) | KDM4CKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6615451 | 0.87 | MAPK14 (0.43) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6616464 | 0.86 | KDM4C (0.42) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6618968 | 0.86 | CRACR2A (0.42) | ACKR3NPC1RAB9AHTTCRACR2A | |
| SCHEMBL6602944 | 0.85 | KDM4C (0.48) | KDM4CMAPK14ACKR3HTR2AKMT2A | |
| SCHEMBL6677022 | 0.85 | NAMPT (0.45) | ACKR3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6616425 | 0.85 | NAMPT (0.40) | MAPK14ACKR3KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |