Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616214 | 0.92 | NAMPT (0.46) | CRACR2ANPC1RAB9ANAMPTHTT | |
| SCHEMBL6677022 | 0.89 | NAMPT (0.45) | CRACR2ANPC1ACKR3RAB9ANAMPT | |
| SCHEMBL6619830 | 0.88 | CRACR2A (0.46) | CRACR2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6616425 | 0.87 | NAMPT (0.40) | NPC1ACKR3RAB9ANAMPTROCK2 | |
| SCHEMBL6616130 | 0.87 | ASAH1 (0.38) | NPC1RAB9AROCK2TSHR | |
| SCHEMBL6616574 | 0.86 | NR1H4 (0.42) | LMNANPC1RAB9ANAMPTHTT | |
| SCHEMBL6616798 | 0.86 | KDM4C (0.44) | CRACR2ANPC1ACKR3RAB9ANAMPT | |
| SCHEMBL6618827 | 0.85 | ACKR3 (0.40) | CRACR2ALMNANPC1ACKR3RAB9A | |
| SCHEMBL6615008 | 0.84 | SMN1; SMN2 (0.47) | CRACR2ALMNANPC1ACKR3RAB9A | |
| SCHEMBL6621069 | 0.84 | CRACR2A (0.44) | CRACR2ANPC1RAB9AROCK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |