Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616425 | 0.92 | NAMPT (0.40) | NAMPTROCK2MEN1KMT2ANPC1 | |
| SCHEMBL6604168 | 0.91 | CRACR2A (0.42) | NAMPTKCNK3CRACR2AACKR3KDM4E | |
| SCHEMBL6673259 | 0.89 | NAMPT (0.41) | NAMPTROCK2MEN1KMT2ARAB9A | |
| SCHEMBL6618968 | 0.89 | CRACR2A (0.42) | NAMPTCRACR2AROCK2NPC1RAB9A | |
| SCHEMBL6603910 | 0.87 | NAMPT (0.42) | NAMPTCRACR2AROCK2KDM4EPOLB | |
| SCHEMBL6618192 | 0.87 | NAMPT (0.36) | NAMPTROCK2MEN1KMT2ANPC1 | |
| SCHEMBL6616574 | 0.87 | NR1H4 (0.42) | NAMPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6608110 | 0.86 | CRACR2A (0.44) | NAMPTKCNK3CRACR2AACKR3KDM4E | |
| SCHEMBL6615270 | 0.86 | CRACR2A (0.44) | KCNK3KCNK9CRACR2AMEN1KMT2A | |
| SCHEMBL6672260 | 0.86 | MEN1 (0.45) | KCNK3KCNK9MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |