Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 4/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613150 | 0.83 | MAPKAPK2 (0.35) | MAPKAPK2HSD17B1ALDH1A1MAPTPTGS1 | |
| SCHEMBL6611968 | 0.69 | CYP19A1 (0.38) | ESR2MEN1ALDH1A1TP53CYP3A4 | |
| SCHEMBL1645904 | 0.68 | MAPKAPK2 (0.42) | MAPKAPK2ALOX15ALOX12PTGS1PTGS2 | |
| SCHEMBL11477205 | 0.66 | PSMB5 (0.43) | MAPKAPK2 | |
| SCHEMBL6808295 | 0.66 | TYR (0.46) | — | |
| SCHEMBL6615687 | 0.58 | MAPKAPK2 (0.39) | MAPKAPK2PTGS1PTGS2 | |
| SCHEMBL12153564 | 0.58 | ESR1 (0.46) | HSD17B1ALOX15ALOX12ESR1ESR2 | |
| SCHEMBL10807822 | 0.57 | — | — | |
| SCHEMBL10633407 | 0.55 | GNG2 (0.40) | MAPKAPK2ALOX15ALOX12ALDH1A1LMNA | |
| SCHEMBL10885614 | 0.54 | PARP1 (0.43) | ALOX15ALOX12MEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381359-A1 | AURONES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002083123-A1 | AURONES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-10-24 | — | — | WO | disclosed |