Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618800 | 1.00 | FGFR1 (0.44) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8103281 | 0.94 | FGFR1 (0.45) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8110919 | 0.85 | TRPA1 (0.55) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6621847 | 0.85 | TRPA1 (0.55) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6618925 | 0.85 | TRPA1 (0.55) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6618612 | 0.82 | MAPK1 (0.49) | FGFR1MAPTALDH1A1TRPA1MAPK1 | |
| SCHEMBL6621230 | 0.82 | MAPK1 (0.49) | FGFR1MAPTALDH1A1TRPA1MAPK1 | |
| SCHEMBL6619870 | 0.79 | BCHE (0.54) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6617130 | 0.79 | BCHE (0.54) | FGFR1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6617887 | 0.77 | NPC1 (0.57) | FGFR1MAPTALDH1A1TRPA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |