Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618925 | 1.00 | TRPA1 (0.55) | TRPA1TRPM8TRPV1NPC1RAB9A | |
| SCHEMBL8110919 | 1.00 | TRPA1 (0.55) | TRPA1TRPM8TRPV1NPC1RAB9A | |
| SCHEMBL6617397 | 0.85 | FGFR1 (0.44) | TRPA1TRPM8TRPV1NPC1RAB9A | |
| SCHEMBL6618800 | 0.85 | FGFR1 (0.44) | TRPA1TRPM8TRPV1NPC1RAB9A | |
| SCHEMBL8110669 | 0.83 | NOS1 (0.43) | TRPA1TRPM8TRPV1MEN1KMT2A | |
| SCHEMBL6617203 | 0.83 | NOS1 (0.43) | TRPA1TRPM8TRPV1MEN1KMT2A | |
| SCHEMBL6621659 | 0.83 | NOS1 (0.43) | TRPA1TRPM8TRPV1MEN1KMT2A | |
| SCHEMBL8103281 | 0.80 | FGFR1 (0.45) | TRPA1TRPM8TRPV1NPC1RAB9A | |
| SCHEMBL6616738 | 0.80 | SMN1; SMN2 (0.58) | NPC1RAB9APDGFRBKDRFLT3 | |
| SCHEMBL6617887 | 0.78 | NPC1 (0.57) | TRPA1NPC1RAB9APDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |