Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215142 | 0.80 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL6616540 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| Ag1295 SCHEMBL925674 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL8499923 | 0.74 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL595944 | 0.73 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL29351353 | 0.73 | SMN1; SMN2 (1.00) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL7229359 | 0.73 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL6616738 | 0.73 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| Hydrochloric Acid SCHEMBL8500142 | 0.72 | SMN1; SMN2 (0.97) | NPC1RAB9ASMN1; SMN2PDGFRBKDR | |
| SCHEMBL17656943 | 0.72 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |