Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705987 | 0.85 | SMN1; SMN2 (0.41) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| SCHEMBL18515663 | 0.77 | NPC1 (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL30798772 | 0.77 | KDM4E (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1GLA | |
| SCHEMBL6215142 | 0.77 | NPC1 (0.73) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| SCHEMBL15010385 | 0.77 | KDM4E (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1GLA | |
| SCHEMBL6616738 | 0.76 | SMN1; SMN2 (0.58) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| Ag1295 SCHEMBL925674 | 0.74 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| SCHEMBL8499923 | 0.74 | SMN1; SMN2 (0.69) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| SCHEMBL6617565 | 0.73 | NPC1 (0.62) | NPC1SMN1; SMN2RAB9APDGFRBKDR | |
| SCHEMBL4132133 | 0.73 | KDM4E (0.52) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656940-B2 | Treatment of cancer. | SUGEN, INC. | 2003-12-02 | — | — | US | disclosed |