SCHEMBL6617627

SCHEMBL6617627

O=S(=O)(O)c1csc2ccccc12.[KH]

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.46
MAPT P10636 3/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
PKM P14618 2/20 0.42
CNR2 P34972 1/20 0.40
PDPK1 O15530 1/20 0.40
ALDH1A1 P00352 2/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2703947 0.98 CYP2A6 (0.47) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL6766434 0.96 CYP2A6 (0.46) CYP2A6MAPTHDAC3HDAC4HDAC1
Hydrochloric Acid SCHEMBL27734063 0.96 CYP2A6 (0.46) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL31287752 0.78 CA2 (0.51) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL288542 0.78 CA1 (0.47) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL1034849 0.78 CA2 (0.51) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL7491058 0.78 CYP2A6 (0.46) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL14089195 0.78 CYP2A6 (0.46) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL29469856 0.78 CA1 (0.47) CYP2A6MAPTHDAC3HDAC4HDAC1
SCHEMBL6628789 0.77 CYP2A6 (0.44) CYP2A6MAPTHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0891362-B1 PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE GLAXO GROUP LTD (GB) 2004-03-17 EP disclosed
US-6215002-B1 CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS GLAXO WELLCOME INC. 2001-04-10 US disclosed
US-6057457-A ENZYME INHIBITORS FOR PROTEASE OR ENZYMES OF HYDROLYSIS GLAXO WELLCOME INC. (US) 2000-05-02 US disclosed
US-5994344-A BRONCHITIS THERAPY GLAXO WELLCOME INC. (US) 1999-11-30 US disclosed