Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 5/20 | 0.44 |
| ▸ | CTSS | P25774 | 5/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.44 |
| ▸ | CTSV | O60911 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614274 | 0.88 | CTSK (0.71) | CTSKCTSLCTSSCTSVCTSB | |
| SCHEMBL4317649 | 0.88 | CTSK (0.71) | CTSKCTSLCTSSCTSVCTSB | |
| SCHEMBL4317659 | 0.88 | CTSK (0.71) | CTSKCTSLCTSSCTSVCTSB | |
| SCHEMBL6404414 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL6215913 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL4811319 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL4811438 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL4811407 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL4811302 | 0.84 | CTSK (0.50) | CTSKPKMCTSLCTSSFFAR2 | |
| SCHEMBL6406972 | 0.77 | CTSK (0.47) | CTSKPKMCTSLCTSSFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |