Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404414 | 0.81 | CTSK (0.50) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL4811319 | 0.81 | CTSK (0.50) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL6215913 | 0.81 | CTSK (0.50) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL4811302 | 0.81 | CTSK (0.50) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL4811407 | 0.81 | CTSK (0.50) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL6406194 | 0.77 | CTSK (0.44) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL6405409 | 0.77 | CTSK (0.44) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL6403780 | 0.77 | CTSK (0.44) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL6617658 | 0.77 | CTSK (0.55) | CTSKFFAR2PKMCTSLCTSS | |
| SCHEMBL14105190 | 0.76 | CTSK (0.50) | CTSKPKMCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | CTSK 1/4885FFAR2 1944/4885PKM 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.