Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617673 | 1.00 | HTR2A (0.45) | HTR2AHTR2CHTR7HTR6NOS3 | |
| SCHEMBL5871718 | 0.94 | HTR1A (0.44) | HTR2AHTR2CHTR7HTR6HTR1A | |
| SCHEMBL5871712 | 0.94 | HTR1A (0.44) | HTR2AHTR2CHTR7HTR6HTR1A | |
| SCHEMBL5871207 | 0.84 | OPRM1 (0.41) | HTR2AHTR2CNOS3NOS1NOS2 | |
| SCHEMBL5871211 | 0.84 | OPRM1 (0.41) | HTR2AHTR2CNOS3NOS1NOS2 | |
| SCHEMBL5871499 | 0.81 | HTR2A (0.40) | HTR2AHTR2CHTR7HTR6HTR1A | |
| SCHEMBL5871502 | 0.81 | HTR2A (0.40) | HTR2AHTR2CHTR7HTR6HTR1A | |
| SCHEMBL5871325 | 0.80 | HTR1A (0.46) | HTR2AHTR2CHTR7HTR6HTR1A | |
| SCHEMBL5870975 | 0.79 | HTR1A (0.55) | HTR2AHTR2CHTR1A | |
| SCHEMBL5871190 | 0.79 | SCD (0.52) | HTR2AHTR2CHTR7HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976732-B1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2004-11-24 | — | — | EP | disclosed |