Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 12/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 12/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619787 | 0.96 | MAPK14 (0.41) | POLBALDH1A1MAPTMAPK14P2RY14 | |
| SCHEMBL6616947 | 0.94 | SSTR3 (0.43) | POLBALDH1A1CTNNB1TCF7L2SSTR3 | |
| SCHEMBL6608341 | 0.92 | POLB (0.44) | POLBALDH1A1MAPTMAPK14P2RY14 | |
| SCHEMBL6615977 | 0.92 | LMNA (0.42) | POLBMAPTMAPK14P2RY14 | |
| SCHEMBL6618517 | 0.91 | KDM4E (0.45) | POLBALDH1A1MAPT | |
| SCHEMBL6614050 | 0.90 | GCGR (0.43) | CTNNB1TCF7L2 | |
| SCHEMBL6613507 | 0.89 | MAPT (0.42) | POLBALDH1A1CTNNB1TCF7L2MAPT | |
| SCHEMBL6616656 | 0.89 | LMNA (0.39) | POLBALDH1A1MAPTMAPK14 | |
| SCHEMBL6616425 | 0.89 | NAMPT (0.40) | POLBALDH1A1MAPTMAPK14 | |
| SCHEMBL6651951 | 0.88 | P2RY14 (0.41) | POLBMAPTMAPK14P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |