Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CHRNE | Q04844 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613783 | 0.96 | KDM4E (0.38) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6620081 | 0.94 | KMT2A (0.43) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6615112 | 0.88 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6618542 | 0.86 | KMT2A (0.37) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6616287 | 0.85 | KDM5A (0.43) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6616753 | 0.85 | KDM5A (0.43) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6618249 | 0.84 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6617913 | 0.83 | KMT2A (0.36) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6618662 | 0.83 | KMT2A (0.38) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL6613131 | 0.82 | KCNJ6 (0.42) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |