Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 10/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 10/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 10/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615720 | 0.90 | ACHE (0.44) | KCNJ6KCNJ5KCNJ3KDM4ENPC1 | |
| SCHEMBL6618575 | 0.88 | NPC1 (0.47) | KCNJ6KCNJ5KCNJ3KDM4ENPC1 | |
| SCHEMBL6617972 | 0.88 | ACHE (0.44) | KCNJ6KCNJ5KCNJ3KDM4ENPC1 | |
| SCHEMBL6616472 | 0.86 | NPC1 (0.47) | KCNJ6KCNJ5KCNJ3PTGDR2KDM4E | |
| SCHEMBL6613783 | 0.86 | KDM4E (0.38) | KDM4ENPC1ALDH1A1CASP3RAB9A | |
| SCHEMBL6617913 | 0.84 | KMT2A (0.36) | DRD2KDM4ENPC1ALDH1A1CASP3 | |
| SCHEMBL6614988 | 0.84 | NPC1 (0.50) | KCNJ6KCNJ5KCNJ3KDM4ENPC1 | |
| SCHEMBL6617632 | 0.84 | MAPT (0.47) | KDM4ENPC1ALDH1A1CASP3RAB9A | |
| SCHEMBL6618430 | 0.82 | ALDH1A1 (0.38) | DRD2KDM4ENPC1ALDH1A1CASP3 | |
| SCHEMBL6617931 | 0.82 | KDM4E (0.39) | DRD2KDM4ENPC1ALDH1A1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |