Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616898 | 0.82 | PDGFRB (0.40) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL6615897 | 0.77 | PDGFRB (0.37) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL6618062 | 0.77 | FGFR1 (0.36) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL6615831 | 0.77 | ADORA2A (0.41) | PDGFRBPDGFRANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6617311 | 0.76 | PDGFRB (0.40) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL8171746 | 0.73 | PDGFRB (0.61) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL6618710 | 0.70 | PDGFRB (0.40) | PDGFRBPDGFRANPC1KDRFLT3 | |
| SCHEMBL479609 | 0.70 | PDGFRB (0.70) | PDGFRBPDGFRANPC1SMN1; SMN2 | |
| SCHEMBL8103024 | 0.69 | FGFR3 (0.37) | PDGFRBPDGFRANPC1KDRFLT3 | |
| Hydrochloric Acid SCHEMBL6283958 | 0.69 | PDGFRB (0.68) | PDGFRBPDGFRANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |