Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 13/20 | 0.37 |
| ▸ | KDR | P35968 | 13/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617240 | 0.92 | PDGFRB (0.40) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6616898 | 0.84 | PDGFRB (0.40) | FGFR3KDRPDGFRBPDGFRAFYN | |
| SCHEMBL6617311 | 0.81 | PDGFRB (0.40) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6615898 | 0.79 | NPC1 (0.36) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6618710 | 0.78 | PDGFRB (0.40) | FGFR3KDRPDGFRBPDGFRAFLT3 | |
| SCHEMBL9138185 | 0.78 | FGFR1 (0.35) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6618062 | 0.71 | FGFR1 (0.36) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL9053687 | 0.70 | PDGFRB (0.43) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6615897 | 0.69 | PDGFRB (0.37) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL6618059 | 0.69 | PDGFRB (0.37) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |