Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.36 |
| ▸ | KDR | P35968 | 8/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617311 | 0.87 | PDGFRB (0.40) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL6616898 | 0.82 | PDGFRB (0.40) | FGFR3KDRNPC1PDGFRBPDGFRA | |
| SCHEMBL6615898 | 0.80 | NPC1 (0.36) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL6618059 | 0.77 | PDGFRB (0.37) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL9138185 | 0.75 | FGFR1 (0.35) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL6615831 | 0.75 | ADORA2A (0.41) | NPC1PDGFRBPDGFRAFYN | |
| SCHEMBL6616314 | 0.75 | PDGFRB (0.45) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL6618710 | 0.72 | PDGFRB (0.40) | FGFR3KDRNPC1PDGFRBPDGFRA | |
| SCHEMBL8103024 | 0.71 | FGFR3 (0.37) | FGFR1FGFR3KDRFGFR2FGFR4 | |
| SCHEMBL8171746 | 0.70 | PDGFRB (0.61) | KDRNPC1PDGFRBPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |