Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 11/20 | 0.47 |
| ▸ | FNTB | P49356 | 11/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617854 | 0.83 | FNTA (0.48) | ALDH1A1LMNAFNTAFNTBUSP2 | |
| SCHEMBL3281222 | 0.83 | MYC (0.53) | ALDH1A1LMNAPOLBHTTKMT2A | |
| SCHEMBL6619460 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAFNTAFNTBUSP2 | |
| SCHEMBL4453090 | 0.73 | ALDH1A1 (0.77) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL1263079 | 0.72 | HDAC6 (0.66) | ALDH1A1LMNA | |
| SCHEMBL1263715 | 0.72 | HDAC6 (0.59) | ALDH1A1LMNA | |
| SCHEMBL6615609 | 0.72 | FNTA (0.50) | ALDH1A1LMNAFNTAFNTBUSP2 | |
| SCHEMBL27478801 | 0.71 | ALDH1A1 (0.46) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL3582934 | 0.71 | ALDH1A1 (0.68) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL3518475 | 0.70 | ALDH1A1 (0.67) | ALDH1A1LMNAUSP2POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |