Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.69 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.69 |
| ▸ | GCGR | P47871 | 8/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | FRK | P42685 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991357 | 0.83 | MAPK11 (0.65) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL413667 | 0.82 | MAPK14 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7989834 | 0.77 | MAPK11 (0.71) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8484309 | 0.76 | KDM4E (0.73) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL28904610 | 0.76 | MAPK13 (0.87) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4569577 | 0.76 | ALOX5 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL19868952 | 0.74 | ALOX5 (0.80) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2649680 | 0.74 | MAPK11 (0.79) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2649978 | 0.74 | MAPK14 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL15075603 | 0.73 | MAPK11 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623126-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |