Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11269806 | 0.98 | HRH3 (0.41) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| SCHEMBL27566475 | 0.93 | HRH3 (0.41) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| Bromide SCHEMBL7418367 | 0.89 | GNAO1 (0.39) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| SCHEMBL11980479 | 0.86 | — | — | |
| SCHEMBL1706687 | 0.84 | — | — | |
| SCHEMBL331124 | 0.84 | HRH3 (0.47) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| SCHEMBL237382 | 0.84 | ITGB3 (0.47) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| Bromide SCHEMBL7417472 | 0.82 | HRH3 (0.37) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| Hydrochloric Acid SCHEMBL10840761 | 0.81 | ITGB3 (0.46) | HRH3ITGB3ITGA2BGNAO1SLC6A4 | |
| SCHEMBL8732145 | 0.81 | GNAO1 (0.46) | HRH3ITGB3ITGA2BGNAO1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100497-B1 | HETEROCYCLYL SULPHONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6358982-B1 | FOR THERAPY OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1100497-A4 | HETEROCYCLYL SULPHONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1100497-A1 | HETEROCYCLYL SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006158-A1 | HETEROCYCLYL SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |