Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651699 | 0.83 | NPC1 (0.48) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL6497228 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1PTGS2HPGDMAPT | |
| SCHEMBL15156844 | 0.81 | HSD17B10 (0.47) | KDM4EALDH1A1PTGS2L3MBTL1HPGD | |
| SCHEMBL14973090 | 0.77 | MAPT (0.53) | ALDH1A1PTGS2MAPTALOX15HSD17B10 | |
| SCHEMBL5285522 | 0.75 | KDM4E (0.53) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL14351822 | 0.74 | ATM (0.61) | KDM4EALDH1A1PTGS2GAAL3MBTL1 | |
| SCHEMBL16597364 | 0.74 | PRMT5 (0.52) | KDM4EALDH1A1GAAMAPTALOX15 | |
| SCHEMBL4483861 | 0.73 | BACE1 (0.61) | KDM4EALDH1A1GAAL3MBTL1HPGD | |
| SCHEMBL5647642 | 0.73 | KDM4E (0.51) | KDM4EALDH1A1PTGS2GAAL3MBTL1 | |
| SCHEMBL5966725 | 0.72 | ALDH1A1 (0.68) | ALDH1A1PTGS2HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485379-A1 | BETA 3-ADRENERGIC RECEPTOR AGONISTS | Pfizer Products Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003072572-A1 | BETA3-ADRENERGIC RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2003-09-04 | — | — | WO | disclosed |