Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949159 | 0.86 | KMT2A (0.57) | PKMALDH1A1POLBGAALMNA | |
| SCHEMBL6621851 | 0.84 | CETP (0.44) | PGREPHX2KCNA5RORCNAMPT | |
| SCHEMBL6623202 | 0.83 | CCR3 (0.42) | PGREPHX2NAMPTALDH1A1KMT2A | |
| SCHEMBL6742058 | 0.82 | NAMPT (0.56) | PGREPHX2NAMPT | |
| SCHEMBL7948923 | 0.80 | KCNH2 (0.52) | — | |
| SCHEMBL6618631 | 0.77 | CA12 (0.41) | EPHX2ALDH1A1KMT2A | |
| SCHEMBL7957186 | 0.77 | HTR1A (0.47) | NAMPT | |
| SCHEMBL6620971 | 0.76 | HRH1 (0.41) | ALDH1A1GAALMNA | |
| SCHEMBL6743525 | 0.75 | CCR2 (0.44) | PGREPHX2NAMPT | |
| SCHEMBL6621505 | 0.74 | KCNA5 (0.48) | KCNA5ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |