Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 4/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620593 | 0.92 | HRH3 (0.39) | HRH3JAK2TYK2EPHX2JAK1 | |
| SCHEMBL6618981 | 0.92 | JAK2 (0.40) | HRH3JAK2TYK2JAK1CRACR2A | |
| SCHEMBL6621181 | 0.91 | LMNA (0.40) | JAK2TYK2JAK1CRACR2AITGB1 | |
| SCHEMBL6618467 | 0.91 | RAB9A (0.39) | JAK2TYK2JAK1CRACR2AITGB1 | |
| SCHEMBL6617364 | 0.91 | CNR1 (0.42) | JAK2TYK2EPHX2JAK1CRACR2A | |
| SCHEMBL6616448 | 0.90 | EPHX2 (0.40) | HRH3EPHX2SSTR3CNR1 | |
| SCHEMBL6614362 | 0.89 | HRH3 (0.43) | HRH3EPHX2SSTR3 | |
| SCHEMBL6618339 | 0.89 | ACKR3 (0.44) | JAK2TYK2ITGB1ITGA4CNR1 | |
| SCHEMBL6617986 | 0.89 | MAPT (0.43) | HRH3 | |
| SCHEMBL6634119 | 0.89 | CNR1 (0.42) | JAK2TYK2EPHX2JAK1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |